An efficient synthesis of carbazoles from PtCl(2)-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols.
نویسندگان
چکیده
The PtCl(2)-catalyzed reaction of 1-(indol-2-yl)-2,3-allenols occurred smoothly to form carbazoles by connecting the 3-carbon atom of indole with the 4-carbon atom of the allenol moiety, referring to the carbon atom connected to the hydroxyl group.
منابع مشابه
Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: scope and mechanism.
A detailed study on the scope of the efficient PtCl(2)-catalyzed synthesis of carbazoles from 1-(indol-2-yl)-2,3-allenols is described. Through isotopic labeling experiments, it is confirmed that the reaction proceeds through a unique metal carbene intermediate, which undergoes subsequent highly selective 1,2-hydrogen migration to afford carbazoles. The reaction shows wide scope and allows the ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 30 شماره
صفحات -
تاریخ انتشار 2009